PHP is bundled with macOS since macOS X (10.0.0) prior to macOS Monterey (12.0.0). Enabling PHP with the default web server requires uncommenting a few lines in the Apache configuration file httpd.conf whereas the CGI and/or CLI are enabled by default (easily accessible via the Terminal program).
Enabling PHP using the instructions below is meant for quickly setting up a local development environment. It's highly recommended to always upgrade PHP to the newest version. Like most live software, newer versions are created to fix bugs and add features and PHP being is no different. See the appropriate macOS installation documentation for further details. The following instructions are geared towards a beginner with details provided for getting a default setup to work. All users are encouraged to compile, or install a new packaged version.
The standard installation type is using mod_php, and enabling the bundled mod_php on macOS for the Apache web server (the default web server, that is accessible via System Preferences) involves the following steps:
Finder or Spotlight to find
     this file may prove difficult as by default it's private and owned by
     the root user.
    
    Note: One way to open this is by using a Unix based text editor in the Terminal, for example
nano, and because the file is owned byrootwe'll use thesudocommand to open it (asroot) so for example type the following into theTerminalApplication (after, it will prompt for a password):sudo nano /private/etc/apache2/httpd.confNoteworthy nano commands:^w(search),^o(save), and^x(exit) where^represents the Ctrl key.
Note: Versions of Mac OS X prior to 10.5 were bundled with older versions of PHP and Apache. As such, the Apache configuration file on legacy machines may be /etc/httpd/httpd.conf.
With a text editor, uncomment the lines (by removing the #) that look similar to the following (these two lines are often not together, locate them both in the file):
# LoadModule php5_module libexec/httpd/libphp5.so # AddModule mod_php5.c
Be sure the desired extensions will parse as PHP (examples: .php .html and .inc)
Due to the following statement already existing in httpd.conf (as of Mac Panther), once PHP is enabled the .php files will automatically parse as PHP.
<IfModule mod_php5.c>
    # If php is turned on, we respect .php and .phps files.
    AddType application/x-httpd-php .php
    AddType application/x-httpd-php-source .phps
    # Since most users will want index.php to work we
    # also automatically enable index.php
    <IfModule mod_dir.c>
        DirectoryIndex index.html index.php
    </IfModule>
</IfModule>
Note:
Before Mac OS X 10.5 (Leopard), PHP 4 was bundled instead of PHP 5 in which case the above instructions will differ slightly by changing 5's to 4's.
DocumentRoot
    
    
     This is the root directory for all the web files. Files in this directory 
     are served from the web server so the PHP files will parse as PHP before
     outputting them to the browser. A typical default path is 
     /Library/WebServer/Documents but this can be set to
     anything in httpd.conf.  Alternatively, the default 
     DocumentRoot for individual users is 
     /Users/yourusername/Sites
    
   The phpinfo() function will display information about PHP. Consider creating a file in the DocumentRoot with the following PHP code:
<?php phpinfo(); ?>
     To restart, either execute sudo apachectl graceful in 
     the shell or stop/start the "Personal Web Server" option in the
     macOS System Preferences. By default, loading local files in the browser 
     will have an URL like so: 
     http://localhost/info.php Or using the DocumentRoot 
     in the user directory is another option and would end up looking like: 
     http://localhost/~yourusername/info.php
    
  The CLI (or CGI in older versions) is 
  appropriately named php and likely exists as  
  /usr/bin/php. Open up the terminal, read the
  command line section of the PHP 
  manual, and execute php -v to check the PHP version of 
  this PHP binary. A call to phpinfo() will also reveal
  this information.